Biomedical Sciences (Joint Health Sciences)

For a full listing of GBS Faculty, visit http://services.medicine.uab.edu/facultydirectory/facultymain.asp
 

Interdisciplinary Themes*

Biochemistry & Structural Biology Theme

Cancer Biology Theme

Cell, Molecular, and Developmental Biology Theme

Genetics and Genomic Sciences Theme

Immunology Theme

Microbiology Theme

Neuroscience Theme

Pathobiology and Molecular Medicine Theme

*

Completion of the training requirements in one of the above interdisciplinary themes provides eligibility for conferral of one of the following PhD degrees:

  •  Biochemistry and Molecular Genetics
  • Cell Biology
  • Cellular and Molecular Physiology
  • Genetics
  • Microbiology
  • Neurobiology
  • Pathology
  • Pharmacology and Toxicology

For more information regarding GBS Interdisciplinary themes and departments, visit the GBS website at http://www.uab.edu/gbs/home/

BMG-Biochem & Molec Genetics Courses

BMG 698. Master s Level Non-Thesis Research. 3-9 Hours.

Non Thesis research credit.

BMG 699. Thesis Research. 1-12 Hour.

Thesis Research . Must be admitted to master level candidacy and have a 3 members approved committee. Must take at least 6 hours of 699 to graduate with MS.
Prerequisites: GAC M

BMG 703. Protein NMR Laboratory Course. 3 Hours.

Principal focus of this course will be on introducing the student to the practical aspects of protein structual determination. This includes basics of operating a high field NMR spectrometer(including field-frequency lock and shinning), introduction to 2D and 3D NMR data collection on peptides and labeled proteins, assignment of NMR peaks, determination of structural constraints (distances and angles), and finally 3D structure.

BMG 706. RNA Bio:Metabolism & Action. 3 Hours.

The role of RNA as an intermediate in gene expression has been clear for many years; however, only recently has the wide array of cellular functions for this macromolecule become clear. This course will dicuss 4 key topics in RNA biology: synthesis, decay, catalytic activicy and regulatory activity. The format will be 1/3 lecture and 2/3 student presentations. Primary literature applicable to these aspects of RNA biology will be the basis for discussion. The goal of this course is to equip students to understand and appreciate the role that RNA plays in diverse, important cell functions.

BMG 726. Biochemistry and Molecular Genetics Seminar. 1 Hour.

Seminars in various topics in Biochemistry and Molecular Genetics.

BMG 732. Mechanisms of Enzyme Catalysis. 3 Hours.

BMG 733. Fermentation Technology. 3 Hours.

BMG 734. Protein Structure. 3 Hours.

Emphasis on structural results derived from X-ray crystallographic analyses.
Prerequisites: CMB 713 [Min Grade: B] and CMB 720 [Min Grade: B]

BMG 741. Advanced Molecular Genetics. 3 Hours.

Mechanisms of gene regulation and rearrangement in bacteria, yeast, and higher eukaryotes.
Prerequisites: CMB 713 [Min Grade: B] and CMB 720 [Min Grade: B]

BMG 742. Biophysical Aspects of Molecular Structure and Function. 3 Hours.

Major modern biophysical methods used in the elucidation of the structure-function relationship of biologically important macromolecules.
Prerequisites: CMB 713 [Min Grade: B] and CMB 720 [Min Grade: B]

BMG 744. Protein Mass Spectrometry. 3 Hours.

Protein Spectrometry.

BMG 746. Transcriptional Factor. 3 Hours.

BMG 747. Connective Tissue Biochemistry. 3 Hours.

BMG 751. Advanced Virology. 3 Hours.

Advanced studies of selected aspects of virology.
Prerequisites: CMB 730 [Min Grade: B]

BMG 753. Intro Macromol Crystallography. 3 Hours.

Theoretical and experimental aspects of protein crystallography. Applications of X-ray diffraction techniques to studying three-dimensional structures of proteins. 999999.
Prerequisites: CMB 713 [Min Grade: B] and CMB 720 [Min Grade: B]

BMG 757. Physical Biochemistry. 3 Hours.

Physical methods for investigating structures of biological molecules. Need backgrounf in calculus and physical chemistry.

BMG 760. Nuclear Magnetic Resonance. 3 Hours.

Nuclear Magnetic Resonance.

BMG 761. Advanced Eukariotic Molecular Biology. 3 Hours.

Advances Eukaryotic Molecular Biology.

BMG 762. Human Biochemistry and Genetics. 2 Hours.

General mammalian biochemistry for medical students and graduate students only.

BMG 769. Graduate Student Research Mtg. 1 Hour.

Monthly meeting of all BMG& BSB graduate students. Second year students and beyond will present their lab research and data. All current BMG& BSB students are required to present and attend monthly meetings. Attendance will be monitored. Grades will be awarded according to presentation and attendance. Course taught fall and spring semesters.

BMG 770. Journal Club in Metabolism. 1 Hour.

This course will be a literature review course that will cover current and pertinent recent papers concerning metabolic pathways, regulation of metabolism, and the impact of various metabolites on gene experssion, cell growth, and differentiation in health and disease. Participation and presentation by each student is required.

BMG 771. Dental Biochemistry. 9 Hours.

Survey of human biochemistry, emphasis on areas of interest to dentists. For dental students only. Prerequisite: Permission of instructor.

BMG 772. Jnl Clb Prot/Mass Spectro. 1 Hour.

This course will be a weekly journal club in the area of proteomics and mass spectrometry. Each week, leading papers in the field will be reviewed by the students in the class. Emphasis will be placed on papers, which focus on the application of these cutting edge technologies to specific biological systems and pathways. Over the course of the semester, a wide range of proteomic applications of mass spectrometry will be covered from the papers reviewed including quantification of proteins, post-transitional modification, biomarker discovery, sample preparation, data analysis, and proteomic experimental design.

BMG 773. Journal Club in Stem Cell Biology. 1 Hour.

Discussion of Stem cell Biology.

BMG 774. Journal Club Cell Signaling. 1 Hour.

The cell signaling journal club will review induction and regulation of cell signalling. Topics will include phosphorylation (tyrosine, serine, and threonine residues), signal transduction and cell stimulation by hormones, cytokines, growth factors and oxidants.

BMG 775. Special Topics in Biochemistry. 2 Hours.

Topics in Biochemistry and Molecular Genetics not covered in lecture courses.

BMG 776. Special Topics in Biochemistry. 1-5 Hour.

Special Topics in Biochemistry and Molecular Genetics not covered in lecture courses.

BMG 777. Special Topics in Biochemistry. 1-5 Hour.

Special Topics in Biochemistry and Molecular Genetics not covered in lecture courses,.

BMG 778. Special Topics in Biochemistry. 1-5 Hour.

BMG 779. Special Topics in Biochemistry. 1-5 Hour.

Special Topics in Biochemistry and Molecular Genetics not covered in lectures.

BMG 780. Special Topics in Biochemistry. 1-5 Hour.

Special Topics in Biochemistry and Molecular Genetics not covered in lectures.

BMG 781. Advanced Special Topics. 1-5 Hour.

Advanced Special Topics not covered in lecture courses.

BMG 782. Advanced Special Topics. 1-5 Hour.

BMG 783. Advanced Special Topics. 1-5 Hour.

Special Topics in Biochemistry and Molecular Genetics not covered in lectures.

BMG 784. Advanced Special Topics. 1-5 Hour.

Advanced Special Tiopics in Biochemistry and Molecular Genetics not covered in lectures.

BMG 785. Advanced Special Topics. 1-5 Hour.

Advanced Special Topics in Biochemistry and Molecular Genetics which are not covered in lectures.

BMG 786. Journal Club in Transcription. 1 Hour.

BMG 790. Journal Club in Developmental Biology. 1 Hour.

BMG 791. Journal CLub in Gene Therapy. 1 Hour.

Journal club in Gene Therapy. Seminar.

BMG 795. Journal Club in Molecular Biology. 1 Hour.

Journal Club.

BMG 796. Journal Club in Advanced Eukaryotic Biology. 1 Hour.

Journal Club.

BMG 798. Doctoral Level Non-Dissertation Research. 1-14 Hour.

Non Dissertation research credit.

BMG 799. Doctoral Level Dissertation Research. 1-14 Hour.

Prerequisites: GAC D

BPY-Biophysical Sciences Courses

BPY 598. Master s Level Non-Thesis Research. 1-12 Hour.

BPY 599. Master s Level Thesis Research. 1-12 Hour.

BPY 698. Master s Level Non-Thesis Research. 1-10 Hour.

BPY 701. Journal Club in Biophysical Sciences. 1 Hour.

BPY 717. Principles of Scientific Integrity. 1 Hour.

BPY 721. Biophysical Chemistry Laboratory. 2-6 Hours.

BPY 722. Biophysical Chemistry Laboratory. 2-6 Hours.

BPY 723. Biophysical Chemistry Laboratory. 2-6 Hours.

BPY 754. Biochemical Kinetics. 3 Hours.

BPY 775. Biochemical Applications of Fluorescence Spectrosc. 3 Hours.

BPY 793. Directed Studies in Biophysical Sciences. 1-6 Hour.

BPY 798. Doctoral Level Non-Dissertation Research. 1-12 Hour.

CB-Cell Biology Courses

CB 500. BioTeach. 3,6 Hours.

For teachers of science courses. Hands on exrepience. McWane Center BioTeach is a graduate-level introductory laboratory course in molecular biology designed for high-school science teachers. UAB faculty provide a lecture series covering topics that include AIDS, tuberculosis, cancer, forensic medicine, tropical diseases, neurobiology, human genetics, sickle cell anemia and ethical issues in genetic research. Lectures are coupled with hands-on, laboratory training in bacterial genetics, mutagenesis, DNA cloning, gel electrophoresis, polymerase chain reaction, DNA sequencing, forensic analysis, and applications of molecular biology. Science teachers will learn how to incorporate the laboratory experiments into their own classrooms and labs. BioTeach is a course in molecular and cellular biology primarily intended for in-service secondary education teachers, but also includes pre-service teachers. Students will receive state-of-the-art lectures from top UAB researchers on subjects that range from the biology of HIV/AIDS to molecular mechanism underlying hypertension. Each lecture is accompanied by a laboratory experience that the teachers can take back into their classrooms. Further, the teachers each develop a lesson plan that provides a format for teaching each of the BioTeach modules during a one-week secondary education science classroom experience. The Course is taught at McWane Science Center and can be taken for 1-6 credit hours, based on the students participation in the course.

CB 601. Dental Gross Anatomy. 8 Hours.

Dental Gross Anatomy 8 hours of graduate credit.

CB 698. Non Thesis Research Cell Biology. 1-15 Hour.

Non thesis research in Cell Biology.

CB 699. Thesis Research in Cell Biology. 1-15 Hour.

Thesis Reseach Cell Biology. Must have 3 member committee approved by the graduate dean and approved for master level candidacy before registering for course.
Prerequisites: GAC M

CB 700. Gross Anatomy of the Thorax, Abdomen, & Pelvis for Teacher Education. 2 Hours.

Human gross anatomy and dissection of the thorax, abdomen, and pelvis. This course will take current and future anatomy educators through the complete gross anatomy of the thoracic, abdominal, and pelvic cavities. Correlations to common medical illnesses and strategies for anatomy education will be emphasized throughout.

CB 710. Macromolecular Crystal. 3 Hours.

CB 712. Journal Club Developmental Biology. 1 Hour.

Journal Club in Developmental Biology.

CB 713. Journal Club in Growth Factors. 1 Hour.

Jornal Club in Growth Factors.

CB 714. Journal Club Calcium Signaling. 1 Hour.

Journal club.

CB 715. Journal Club Biochemical Approaches to Cell Biology. 1 Hour.

Biochemical Approaches to Cell Biology Journal Club.

CB 716. Journal Club The Molecular Basis of Signalling in the Nervous System. 1 Hour.

The Molecular Basis of Signalling in the Nervous S.

CB 720. Journal Club Developmental Neurobiology. 1 Hour.

Developmental Neurobiology Journal Club.

CB 721. Cell Biology Laboratory Rotations. 5 Hours.

Laboratory Rotations.

CB 722. Journal Club Vascular Biology. 1 Hour.

Vascular Biology Journal Club. This course will present the latest understanding of the cellular and molecular biology of the vascular system, including discussions of cardiovascular control by the brain, hypertrophy and hyperplasia in the heart and blood vessels and the regulation of pressor and depressor hormones.

CB 723. Journal Club Membrances and Clycobiology. 1 Hour.

Journal Club Membrances and Glycobiology.

CB 724. Special Topics in Cell Biology. 3 Hours.

Topics in Cell Biology.

CB 728. Advanced Cell Biology. 3 Hours.

The course will cover an introduction to biochemical methodologies used in contemporary laboratories. Classic publications that illustrate novel biochemical schemes and address basic questions in cell biology will be analyzed and discussed.

CB 729. Mechanisms of Signal Transduction. 3 Hours.

This course will cover pathways of signal transduction in development, growth factor signaling, cytokine signaling in hematopoietic systems, signaling during inflammation, and mechanisms of signaling termination.

CB 730. Molecular Basis of Conformational Diseases. 3 Hours.

Moecular Basis of Conformational Diseases.

CB 731. Molecular Chaperones and Clinical Potential. 3 Hours.

Class goal is understanding basic mechanisms by which molecular chaperones recognize, bindand fold non-native polypeptides. Applications in immunotherapy for cancer treatment will be discussed.

CB 732. Developmental Biology. 3 Hours.

Basic mechanisms of vertebrate development.

CB 733. Advanced Topics in Cell Cycle and Cancer Genetics. 3 Hours.

Regulation of cell cycle and checkpoint control, genome instability, tumor suppressor genes, oncogenes and cancer epigenetics.

CB 734. Alzheimer s Disease and Related Dementias. 3 Hours.

CB 735. Mechanisms of Writing a Scientific Paper and NIH Grant. 3 Hours.

Mechanisms of Writing a Scientific Paper and NIH Grant.

CB 736. Cell Cycle and Cancer Genetics. 3 Hours.

Cell Cycle and Cancer Genetics.

CB 737. Cell-Matrix Interactions and Disease. 3 Hours.

Developmental Biology.

CB 738. Selected Topics in Cell Biology. 3 Hours.

CB 740. Research in Cell Biology. 1 Hour.

Research in Cell Biology.

CB 745. Protective/Pathogen T Cell Res. 3 Hours.

CB 746. Cell Cycle and Cancer Genetics. 3 Hours.

Cell Cycle and Cancer Genetics.

CB 747. Cell Biology Seminar. 1 Hour.

Seminars in Cell Biology.

CB 748. Special Problems in Cell Biology. 1-5 Hour.

SPECIAL PROBLEMS IN CELL BIOLOGY.

CB 750. Graduate Gross Anatomy. 6 Hours.

Lectures, demonstrations, and dissection of all systems and regions of human body.

CB 751. Tissue Injury and Repair. 1 Hour.

CB 752. Graduate Histology. 3 Hours.

Light microscopic features and ultrastructure of cells, fundamental tissues, and organ systems.

CB 753. Teaching Assist Grad Histology. 1-2 Hour.

CB 755. Graduate Neuroanatomy. 4 Hours.

Gross and microscopic preparations of brain and spinal cord. Functional significance of tracts and nuclei.

CB 779. Special Problems Neuroanatomy. 1-4 Hour.

Special Problems in Neuroanatomy.

CB 788. Molecular Mechanisms of Neurodegeneration Diseases. 1-4 Hour.

Directed Readings.

CB 790. Developmental Neurobiology. 4 Hours.

Developmental Neurobiology.

CB 798. Doctoral Non-Dissertation Research. 1-15 Hour.

Non dissertation research credits.

CB 798B. Non-Dissertation Research. 1-15 Hour.

CB 799. Doctoral Level Dissertation Research in Cell Biology. 1-15 Hour.

Dissertation research. Must have graduate dean approved 5 member committee and doctoral approved candidacy to take research credits.
Prerequisites: GAC D

CB 799B. Dissertation Research. 1-15 Hour.

Prerequisites: GAC D

GBS-Grad BIomedical Sciences Courses

GBS 700. Molecular Neurodegeneration. 3 Hours.

Course provides clinical exposure to the evaluation and care of patients with cognitive disorders through a combination of didactic sessions and practicum visits, including observation of visits for patients with developmental and age-related cognitive impairment, neuropsychological testing, and functional MRI.

GBS 703. Research Analysis & Presentation. 1 Hour.

This course is designed to help graduate students with oral presentation skills by exposing them to the style of presentation expected in national meetings. This course is open to any JHS/SOM graduate student, but it is a required course for all students in the GBS PBMM Theme.

GBS 704. Introduction to Experimental Medicine. 2 Hours.

This course will consist of interactive lectures, discussions, and scientific literature reviews demonstrating general principles in biomedical sciences and how defects in these processes are related to human disease or birth defects. Faculty will discuss scientific rationale, logic, and approaches to investigate these processes and provide examples from the primary literature or research ongoing in their laboratories. This will include examples of translational studies designed to develop new therapeutic approaches to treat disease. Students will be evaluated based on written assignments, participation in discussions, and on a class presentation. Required for all first year PBMM Theme students.

GBS 705. Biology of Neurodevelopmental Disorders. 3 Hours.

This course will review how normal cellular maturation, signaling, and circuitry are disrupted in a wide variety of neurodevelopmental disorders. Topics will include: Once neurons arrive in their final locations, what events occur to allow for integration into a network, plasticity of circuits (including critical periods of plasticity), and balance of excitation and inhibition? Why is the developing brain sensitive to inflammation, over-excitation, mood stabilizers (as well as antipsychotic medications and other drugs), and malnutrition? How can disruptions in neuronal maturation give rise to distinct neurodevelopmental disorders?.

GBS 707. Basic Biochemistry and Metabolism. 2 Hours.

This course is intended to provide students a rigorous background in the principles of biological chemistry. The principles taught are those we believe student should master and include the application of these principles to research protocols and performance. Must be admitted into one of the Graduate Biomedical Sciences (GBS) Themes. Required of all first year GBS students.

GBS 708. Basic Genetics and Molecular Biology. 2 Hours.

This course is intended to provide students with a strong foundation in basic genetics and basic molecular biology so that students are able to apply and understand fundamentals in their lab research. Must be admitted into one of the Graduate Biomedical Sciences (GBS) Themes. Required of all first year GBS students.

GBS 709. Basic Biological Organization. 2 Hours.

This course is intended to provide students with exposure to the fundamentals of basic cell biology and begin to build a foundation of knowledge that will be needed as the student progress along the scientific path. Must be admitted into one of the Graduate Biomedical Sciences (GBS) Themes. Required of GBS first year students.

GBS 710. Cell Signaling. 2 Hours.

This course covers major extracellular and intracellular signal transduction cascades that regulate animal development and physiology. Topics include the mitogen activated protein kinase cascade, transforming growth factor beta, insulin, and cytokines.

GBS 712. Cellular and Molecular Aspects of Developmental Biology. 2 Hours.

The goal of this course is to provide an introduction to the fundamentals of vertebrate developmental biology. The course will consist of faculty lectures and research paper discussion groups covering a broad range of developmental issues from fertilization to organogenesis.

GBS 714. Developmental Neuroscience. 2 Hours.

The course will utilize the scientific literature and faculty lectures to cover a broad range of topics related to the mechanisms of building a brain. The topics covered range from neural induction in early development, to axonal guidance and synapse formation, to neuro-gial interactions in the adult nervous system.Grading is based on exams and student participation.

GBS 715. Skeletal Development and Disease. 3 Hours.

This class is designed for understanding Cellular and Molecular Signaling essential for the normal development and remodeling of skeleton and for learning genetic mechanisms associated with skeletal diseases and pathology.

GBS 716. Grantsmanship and Scientific Writing. 2 Hours.

The objective of the course is to teach students how to effectively write grant proposals. This course will provide hands on training in the preparation of a grant application and demonstrate effective strategies for assembling a successful proposal. With guidance from the faculty, the students will write a NIH style proposal on their dissertation research topic. After the proposal is complete, each grant will be reviewed in a mock NIH study section. Based on the comments from the study section, the student will revise the application and submit the proposal to his/her thesis committee as part of the qualifying examination for admittance into candidacy. This course is only for advanced students, not first year students.

GBS 717. Methods and Scientific Logic. 1 Hour.

Methods and Logic in Science is a literature-based class in which students have to critically analyze primary research publications. The overall objective is to teach the students to evaluate the primary literature they will rely on for their careers.

GBS 718. Graduate Histology. 3 Hours.

This course will cover the specialized cell biology and microscopic anatomy for each of the mammalian organ systems, as well as consider current research with regards to each system. The objective is to understand how cells organize into tissues and organ systems and how these systems function in the body, as well as appreciate the microscopic appearance of cells, tissues and organs. Prerequisites include completion of the first year of a graduate program and active engagement in research.

GBS 720. Genomic Structure and Function. 2 Hours.

This course will cover a wide variety of topics related to this topic, including genetic variation and polymorphisms, alternative splicing, microRNAs, and novel sequencing and microarray technologies.

GBS 721. Genetic Epidemiology. 2 Hours.

This course will cover a wide variety of different bioinformatics applications, which will be taught through use of available on-line bioinformatics resources. The topics covered will include: introductions to large-scale, generic databases at NCBI, European Bioinformatics Institute, SwissProt, PDB, UniProt and Ensembl; Sequence analysis systems such as BLAST, ORF-Finder and GENSCAN, Multiple Sequence Analysis, gene identification in DNA and an introduction to the Human Genome Project; resources that are used in Microarray Data Analysis; Protein sequence analysis using Pfam, Prosite, Prints, Blocks, Protein structure analysis using SCOP, CATH; structural bioinformatics, secondary structure calculation, homology modeling, structure prediction, protein folding, protein-ligand docking and molecular dynamics.

GBS 722. GGS Bioinformatics. 2 Hours.

This course will cover a wide variety of different bioinformatics applications, which will be taught through using bioinformatics resource websites. The topics covered will include: introductions to large-scale, generic databases at NCBI, European Bioinformatics Institute, SwissProt, PDB, UniProt and Ensembl; Sequence analysis systems such as BLAST; statistical genetics; use of R/Bioconductor in research; super computing; Systems Biology; brief introduction into programming languages; resources that are used in Next Generation Sequencing (NGS) analysis, which includes variant discovery, transcriptomics, ChIP-Seq, epigenetics, micro-RNA, de novo assembly, microbiome and metagenomics.

GBS 723. Model Systems for Genetic Analyses. 2 Hours.

The course will provide students with an in-depth knowledge of the different animal models used for analyses of gene function and genetic pathways. Topics include transgenic and knockout mouse technologies and strategies, large scale genetic screens in C. elegans and Drosophila, and modeling human genetic diseases in zebrafish.

GBS 724. Principles of Genetics: Inheritance and Disease. 2 Hours.

Course required for first year GBS GGS theme students and offered to upper-level students as advanced course. This course will cover recessive, dominant, X-linked, and mitochondrial inheritance, as well as basic cytogenetics, chromosome abnormalities, and epigenetics.

GBS 725. GGB Grant Writing. 2 Hours.

The objective of the course is to teach students how to effectively write grant proposals. This course will provide hands on training in the preparation of a grant application and demonstrate effective strategies for assembling a successful proposal. With guidance from the faculty, the students will write a NIH style proposal on their dissertation research topic. After the proposal is complete, each grant will be reviewed in a mock NIH study section. Based on the comments from the study section, the student will revise the application and submit the proposal to his/her thesis committee as part of the qualifying examination for admittance into candidacy.

GBS 726. Advanced Medical Genetics. 3 Hours.

This course will focus on the medical application of advances in genetics and genomics. Topics include chromosome structure and function and major types of chromosomal abnormalities, cancer genetics and cytogenetics, inborn errors of metabolism, current strategies for detection of mutations associated with genetic disorders, genetic risk assessment and population genetics, and genomic approaches to diagnosis and risk stratification.

GBS 727. Advanced Human Genomics. 1-4 Hour.

This course will cover the conceptual basis, major discoveries, and unsolved problems in human genomics, with an emphasis on disease applications. The goal is to make students conversant with the structures, functions, and natural histories of human genomes, the computational and experimental methods used to establish that knowledge, the applications of genomics to medical research, and the broader impacts of genomic research on the community. Each topic will be covered by an approximately 90-minute lecture from a subject-specific PI coupled to reading of pieces of primary literature. Students will also participate in 3 student-led journal clubs in which one or more papers are discussed in detail with the help of the teaching faculty. We will also perform 3 interactive sessions to teach basic computational skills in Unix, Perl and R. Grading will be determined by: discussion interaction, computational problem sets due in weeks 4, 6, and 8, and a “final” project in which students perform a small but cohesive set of bioinformatic analyses to address a question of their choosing, subject to approval/discussion with the teaching faculty. Format: Each of the 7 weeks will include two, 90 minute lectures performed at UAB. In weeks 2, 4, and 6, we will convene at HudsonAlpha for four-hour sessions. Each four-hour session will include ~1 hour of paper discussion, ~1 hour of teaching on a relevant computational topic, and ~2 hours of hands-on interactive data manipulation with commonly used data types and computational tools. Course meets both on UAB Campus and at Hudson-Alpha in Huntsville.

GBS 728. Bio-Nano Technology JC. 1 Hour.

This journal club will focus on the use of biological materials as paradigms, structural scaffolds, and active elements of nanoscale materials.

GBS 729. Translational Approaches in Neurodegeneration. 3 Hours.

With the current emphasis on "bench to bedside" strategies, successful translational research approaches may be helpful for a productive career in academic and industrial settings. This course uses the field of neurodegeneration as a vehicle for conceptualization to the failures, current challenges, and successes of different translational approaches. This course emphasizes active learning principles by placing students into scenarios of direct relevance to a career in science (e.g., emulation of study section discourse, formal critical debate that happens at international symposia, and informal discussions between colleagues).

GBS 730. Introduction to Neurobiology (Dauphin Island Course). 3 Hours.

Hands on experiments and classroom lectures onsite at the Dauphin Island Sea Lab. Students live onsite the entire course. Required of first year Neuroscience Theme students. Other students in neuro labs should seek permission from the Neuroscience Theme Director, if there are available slots.

GBS 731. Principles of Cellular Neuroscience. 3 Hours.

Overview and study of various aspects of cellular neuroscience.

GBS 732. Graduate Neuroscience. 2 Hours.

The module provides the student with an integrated basic and clinical sciences view of the structure and function of the nervous system in health and disease. The module is designed to prepare students for future clerkships by providing them with a working knowledge of the developing and mature nervous system, with a perspective that ranges from molecular to behavioral. The neuroanatomical, neurochemical and neurophysiological aspects of the brain and spinal cord are balanced by large and small group discussions of the pathology and treatment of neurological and psychiatric diseases. Course last offered Spring 2015.

GBS 733. Disease of the Nervous System. 2 Hours.

Major advances have been made in understanding diseases of the nervous system at a cellular and molecular level. Several new findings have had direct therapeutic implications and have resulted in the development of novel drugs or new disease management strategies. This course intends to review the most common brain and CNS disorders.

GBS 734. Neuroscience Historical Literature JC. 1 Hour.

Discussion of historical neuroscience literature, giving students an appreciation of the early foundations of neuroscience research. Required of all 2nd year Neuroscience Theme students.

GBS 736. Cognition Journal Club. 1 Hour.

Journal club exploring various literature on cognition and cognitive disorders.

GBS 737. Neuro Student Summer Seminar Series. 1 Hour.

This seminar series features neuroscience graduate students presenting their research to their peers. Required each year for students in the Neuroscience Theme.

GBS 738. Experimental Design. 2 Hours.

This course is to assist students in the process of designing hypotheses and experiments in the research lab.

GBS 739. Neuropharmacology. 3 Hours.

Advanced course which will focus on the mechanism of action of CNS-active drugs. The first one-third of the course will consist of lectures that emphasize basic principles of neuropharmacology including neurotransmitter and receptor concepts, pharmacokinetics, pharmacodynamics and pharmacogenomics. The next two-thirds of the course will focus on the mechanism of action of different drug classes, including classical behavioral and biochemical studies, as well as genetic and molecular analyses of drug action. In each section, the instructor will give an overview lecture followed by student presentations. Student performance will be evaluated based on homework, oral presentation and written examination.

GBS 740A. Introduction to Immunology Part 1. 2-4 Hours.

Introductory Immunology is a team-taught survey course that covers basic concepts of innate and adaptive immunity. These integrated series of lectures provide a firm foundation in immunology, especially for those with minimal immunology background, and serve as an important refresher for the developing immunologist. Required for first year Immunology Theme students. This is Part 1 of 2.

GBS 740B. Introduction to Immunology Part 2. 2-4 Hours.

Introductory Immunology is a team-taught survey course that covers basic concepts of innate and adaptive immunity. These integrated series of lectures provide a firm foundation in immunology, especially for those with minimal immunology background, and serve as an important refresher for the developing immunologist. Required for first year Immunology Theme students. Part 2 of 2.

GBS 741. Lymphocyte Biology. 2 Hours.

This is not an advanced course. The objective of this course is to provide first year immunology students with the opportunity to gain a more in-depth understanding of selected aspects of lymphocyte biology. Possible topics include T cell subsets, B cell biology, lymphocyte activation, and transplantation immunology. The course is literature intense, and students are required to read and present numerous scientific papers.

GBS 743. Innate Immunity. 2-3 Hours.

The study of innate immunity has made a resurgence in recent years and its critical role, not only in host defense against invading pathogens, but in the development of adaptive immune responses is now appreciated. This course will provide an in-depth look at selected aspects of the innate immune response including the cellular and molecular components critical to its development. The course will involve student presentations on selected topics.

GBS 744. Mucosal Immunology. 2-3 Hours.

The mucosal immune system is essentially the primary site of interaction between invading pathogens and the immune system. Mucosal immunity has always been a strength of the immunology community at UAB and is rarely covered at most other institutions. This class will provide in-depth analysis of the structural features that distinguish the mucosal immune system from the peripheral immune system. Features of innate and adaptive immunity as they relate to mucosal immune responses will also be covered. The course will involve student presentations on selected topics.

GBS 745. Neuroimmunology. 2-3 Hours.

The purpose of this course is threefold; 1) to provide students with a basic overview of immunology and neuroscience in conjunction with a specific focus on how neuroinflammatory processes affect the brain, 2) to teach students basic neuroanatomy of the brain, and 3) to have students understand the clinical implications of neuroinflammatory diseases by attending rounds with clinicians. How the immune system influences the brain is an emerging field in neuroscience research and is currently not being addressed in a graduate or medical course.

GBS 746. Special Topics in Biomedical Sciences I. 1-4 Hour.

Varying topics offered to advanced graduate students in the GBS program.

GBS 746J. Exercise Medicine Journal Club. 1 Hour.

Exercise training in various forms induces a complex array of coordinated cellular and molecular processes that improve symptoms and co-morbidities associated with numerous chronic conditions including musculoskeletal, cardiorespiratory, metabolic, immunologic, and neurologic disorders—and disease risks associated with chronic physical inactivity are widespread. Understanding the biological mechanisms underlying exercise-induced adaptations and their clinical utility in disease treatment and prevention is therefore a truly interdisciplinary effort. Students will interact with scientists and clinicians from several disciplines, and will present and discuss the latest and most impactful exercise-based research in both human and animal model systems. Attendance is required.

GBS 747. Special Topics. 1-6 Hour.

Varying topics offered to advanced graduate students in the GBS program.

GBS 747J. Circadian Clocks Journal Club. 1 Hour.

Circadian Clocks Journal Club. In this journal club, we will bring together researchers with diverse perspectives, specialized techniques, and scientific backgrounds in order to develop a take-home message from recent circadian literature that may be applicable to all of our specific fields. Nearly all organisms possess an endogenous circadian clock that governs a wide array of rhythms, from biosynthetic to behavioral, and synchronizes (entrains) them to the 24-h environmental day-night cycle. The central circadian clock in the suprachiasmatic nucleus of the hypothalamus orchestrates rhythms in many peripheral clocks located throughout the brain and body, resulting in 24-h regulation of many physiological processes (including sleep and reproduction, metabolism, organ function, and seasonal behaviors). This regulation allows for a predictive, rather than purely reactive, homeostatic control. In humans, dysregulation of the circadian system has been implicated in some insomnias, cancers, affective disorders, and in aging and cognitive impairment. The discovery and characterization of oscillating “circadian clock” genes during the last decade has been largely due to cross-talk between researchers working on fruitflies and mice; this approach fueled insights into the likely design principles underlying the intracellular oscillatory machinery. Similar discussion and collaboration at a systems level of analysis may lead to new discoveries and approaches. Students will choose and present papers from any field as long as there is a circadian component to the paper.

GBS 748. Special Topics. 1-4 Hour.

Varying topics offered to advanced graduate students in the GBS program.

GBS 749. Mitochondria in Health, Disease & Toxicology. 3 Hours.

The course will consist of lectures given by faculty members on specific topics in the field of mitochondrial biology and toxicology. These lectures will be complemented by student presentations of original research articles, which are related to the presented subject matter and that place the discussed topic into the context of human health, disease, and toxicology. This format will allow for students to gain a solid understanding of normal mitochondrial physiology, which they can then use to explore the literature to reveal the importance of mitochondrial dysfunction in human diseases and toxicology responses. This course will be guided by the Course Director and other faculty members who will assist in the selection of relevant readings and facilitate in-class discussions among the students. Student must have successfully completed a doctoral level biochemistry or cell biology course.

GBS 750. Nerves, Muscles and Bones. 2 Hours.

This course will include an overview of basic cellular physiology and the neurological and musculoskeletal systems. Neurologic and neuromuscular diseases such as Parkinson's, multiple sclerosis, and myasthenia gravis will be discussed, along with primary myopathies (e.g., dystrophinopathies), joint diseases (osteoarthritis, acute arthritis, arthropathies, fibrosing disorders), and bone diseases (osteoporosis, osteopetrosis, osteonecrosis).

GBS 751. Heart, Lung and Kidney. 2 Hours.

Course will introduce the exquisitely integrated cardiovascular, respiratory, and renal systems. This integration will be reinforced with examination of numerous disease states (acidosis, hypertension, heart failure, atherosclerosis/chronic vascular inflammation, genetic and environmentally-induced pulmonary diseases, chronic kidney disease).

GBS 752. GI, Endocrine and Immune System. 2 Hours.

This four-week course will examine the physiology and pathobiology of the gastrointestinal tract, followed by sub-modules focused on endocrinology and immunology. Students will learn how the endocrine system integrates homeostasis of multiple organ systems through a comprehensive approach—influencing all systems examined in the previous modules. The mechanisms and consequences of abnormal GI function (e.g., peptic ulcer disease, diarrhea), endocrine dysregulation (type II diabetes mellitus, gigantism, hyperthyroidism, Cushing’s syndrome), and immune dysfunction (HIV, rheumatoid arthritis, type I diabetes mellitus) will be discussed. The course is divided into three blocks (GI, Endocrine, & Immune)—each with a block leader. Requirement This course is designed for doctoral students admitted to the Graduate Biomedical Sciences (GBS) PhD program and is required for GBS students in the Pathobiology and Molecular Medicine (PBMM) theme. GBS students from other themes are welcomed and encouraged to take this course as an elective. Individuals outside the GBS program must contact the course director before enrolling in the course to check availability.

GBS 753. Pharmacology and Molecular Medicine. 2 Hours.

Students taking this course will be expected to have a thorough understanding of normal and abnormal organ system function as discussed in the three-modules described above. Lectures will build on that foundation to cover recent advances in drug design and development based on approaches of molecular pharmacology and molecular medicine. In addition, drug targeting strategies that take advantage of specificity in cellular structure and cell signaling processes will also be discussed.

GBS 754. Autophangy in Disease and Medicine. 3 Hours.

This advanced course reviews the pathobiology of autophagy and how it is essential for survival, differentiation, development, and homeostasis and how it serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

GBS 756. Cardiometabolic Disease Journal Club. 1 Hour.

The review of recently published articles focused on understanding the complex gene-environment interactions that contribute towards common metabolic diseases, such as obesity, diabetes, and cardiovascular disease. Articles most commonly reviewed range from the whole organism (e.g., physiology, energy balance, metabolism, endocrinology, genetics) to individual cells (e.g., cellular metabolism, signal transduction, and transcriptional regulation), in both animal models and humans. In addition, articles investigating novel lifestyle (e.g., diet and/or exercise), pharmacological (e.g., appetite suppressants), and surgical (e.g., gastric by-pass) interventions designed to treat cardiometabolic diseases are routinely discussed.

GBS 757. Biology of Disease. 3 Hours.

Biology of Disease is a comprehensive course in general pathophysiology designed for graduate students in the GBS program or other science related graduate programs. This course will begin with an overview of general anatomy and histology and then will investigate basic pathophysiologic principles emphasizing pathogenic mechanisms and clinically important diseases where current research areas will be highlighted. The biomedical science students will learn the mechanisms involved in disease processes and will develop an understanding of diseases and clinical medicine to help them converse knowledgeably with medical colleagues and target their research towards clinically relevant issues. Requirements: It is expected, although not required, that students will have a background in biochemistry, cell biology, microbiology, and immunology and will have successfully completed the first year GBS courses.

GBS 758. Cardiovascular Biology. 2 Hours.

Requirement: This course is designed for doctoral students admitted to campus-wide PhD programs in the biomedical and basic sciences, post-doctoral fellows, medical students, residents, staff, and members of the faculty interested in the latest advances and approaches in cardiovascular biology. Prerequisite: Successful completion of doctoral level biochemistry/molecular biology course..Description: The course will consist of didactic lectures given by faculty members from UAB and guest lecturers from other institutions on a specific topic in the field of cardiovascular biology, which will then be followed up by student presentations of original research articles which are related to the presented subject matter and that place the discussed topic into the context of human health and disease. This format will allow for students to first gain a solid understanding of normal and pathological aspects of cardiovascular physiology, the basic experimental approaches that can be used in bench to bedside studies and the current perspectives on a broad range of current hot topics in the field. In addition, this course has unique components including instruction on how to review a research paper and prepare for an interview for an entry level position (e.g. postdoctoral) in academia and/or industry. These exercises will provide an appreciation of the issues related to a career scientific research. This course will be guided by the Course Director and other faculty members who will assist in the selection of relevant readings and facilitate in-class discussions among the students. Objectives: The primary objective of this course is for students to gain expertise in the field of cardiovascular biology through discussion and exposure to the latest research and concepts in the field with a particular focus on the translation of molecular mechanisms to our understanding of the etiology of the disease. A secondary goal is for the participant to appreciate fundamental issues and expe.

GBS 759. Developing Presentation Skills for Microbiological Research. 1 Hour.

The goal of this course is to provide students with the skills to critically evaluate and present their research. In initial sessions, students will learn how to give an effective presentation. Students will then develop their own presentation with advice from a student advisor as well as the course director or other faculty members. Following the presentation, students will address questions from an audience of students and faculty. The students and faculty will also provide written evaluations of the presentation. The student advisor will develop skills in critiquing presentations and introducing a scientific speaker to an audience.

GBS 760. Prokaryotic Genetics and Molecular Biology. 2 Hours.

This course is designed to familiarize students with advanced knowledge in recombination, transcription, translation, regulation of gene expression, transport mechanisms and protein export. The students will learn the fundamental principles how structural components of bacterial cells are built and how bacteria-specific metabolic pathways can be exploited by antibiotics. We will also cover state-of-the-art technologies such as whole genome sequencing, microarray experiments, methods to analyze protein-protein interactions and the metabolome of bacteria. In this course, we emphasize the training of critical thinking and foster the ability of the students to design their own experiments to solve scientific problems in bacteriology. The goal of the course is to provide a strong foundation for advanced bacteriology classes and for doing research in any bacteriology lab.

GBS 762. Virology. 2-3 Hours.

This course is designed to familiarize students with the general steps involved in viral lifecycles and use this knowledge as a framework for understanding the similarities and differences in the lifecycles of (+) and (-) stranded RNA viruses, DNA viruses, and retroviruses. The course also covers the role of viruses in oncogenesis, the origin and evolution of viruses, the innate immune response to viral infections, and the development of antiviral chemotherapeutics. The goal of the course is to provide a strong foundation for advanced virology classes and to provide students with enough background in virology to be comfortable teaching in a college level microbiology class.

GBS 763. Microbial Pathogenesis. 2-3 Hours.

The course in Bacterial Pathogenesis contains introductory lectures that provide an overview of major concepts including virulence factors, and host immune mechanisms. Most of the lectures describe the unique aspects of specific bacterial (and fungal) pathogens. Although many of the most important medical pathogens are covered, the course focuses especially on those bacterial and fungal pathogens studies most intensively at UAB. Each week students will be given a quiz based on the lectures of the preceding week. To answer the questions, an understanding of the lecture material will be needed. The questions are designed to help the students thinking about hypotheses and concepts in Bacterial Pathogenesis. The final grade in the course will be based on these quizzes and the student participation in discussions.

GBS 764. Structural Biology for Micro. 2-3 Hours.

Advanced Course. Structural biology is central to understanding the function of biological macromolecules and is to relevant to all fields of modern biological science. This course will provide a basic introduction to the elements of structural biology including the levels of protein structure (primary, secondary, tertiary, quaternary), the basis of structure determination by X-ray crystallography, NMR, and cryo-electron microscopy, and will explore the structure/function relationships in select systems.

GBS 765. Hybrid Structural Techniques as Applied to Cellular & Molecular Biology. 3 Hours.

This course will focus on the use of X-ray crystallography, Cryo-Electron microscopy and Image Reconstruction, NMR, and Mass Spectrometry to obtain structures of biological macromolecules. Each component will be taught separately. Each module will focus on insuring the student has a basic understanding of the essential principles of the technique and its practical application. Examples will generally be drawn virology and immunology. Students will be actively involved through assigned problem sets and in class discussion. This material in this course will be targeted towards second year graduate students and non-specialists.

GBS 766. Inflammation Journal Club. 1 Hour.

Inflammation Journal Club presents the state of the art papers that fall broadly in the area of inflammation, which include aspects of basic cellular and molecular mechanisms, animal models and immunopathology of human diseases including, infectious diseases, cancer and chronic lung diseases.

GBS 767. Structural Basis of Viral Replication. 3 Hours.

This course will focus on understanding the mechanistic basis of viral replication through the lens of structural biology. The course will cover mechanisms of viral entry, transcription, translation, genome replication, transport, assembly, and exit as well as immune evasion. The focus will be on systems where a particular step in the replication cycle is well understood rather than on any particular virus family. Students are expected to have a basic knowledge of virology and will acquire sufficient knowledge of the techniques of structural biology to critically analyze primary literature.

GBS 768. Communicating Science: Reading, Writing and Presentation. 2 Hours.

This first year graduate level course will teach students how to make formal scientific oral presentations and how to write a paper for publication in a scientific journal.

GBS 769. Carcinogens. 3 Hours.

The course covers advanced topics from oncogenes and tumor suppressor genes to cell cycle and DNA repair.

GBS 770. Pathobiology of Cancer. 2-3 Hours.

Students will gain an understanding of the pathology of cancer in general and an appreciation of the gross, histologic and molecular pathology of cancers of multiple organs, including the brain, lungs, breast, prostate, colon, bone, bone marrow and lymph nodes. The students will learn the basis of the pathologic classification of cancers of particular organs, including the gross, microscopic and molecular features that aid in classification. Then the clinical implications (i.e., prognostication and treatment) of the classification systems will be discussed. Also, current controversies and topics of research interest may be introduced. In addition, several lectures will focus on the epidemiology of cancer and translational research in cancer, including animal models of cancer. Course offered every even year. Required for Cancer Biology Theme students. If taking it for advanced credit, register for 3 hours.

GBS 774. Cancer Immunology. 2-3 Hours.

A summary of key signaling pathways that regulate cancer cell growth, death and behavior will be presented. An intense evaluation of mechanisms involved in pro-and anti-tumor immunology will be presented along with theoretical aspects of cancer immunotherapy. Required for first year CANB Theme Students.

GBS 775. Cancer Treatment. 3 Hours.

Students will study current theories regarding chemotherapy, radiation therapy, chemoprevention and imaging. Students will also be exposed to state-of-the-art for each of these treatment/diagnostic modalities. This course uses a combination of textbook and literature readings and classroom discussions to provide students with an understanding of the different classes of drugs used to treat cancer. The course focuses on the mechanisms of drug action, the basis for selectivity and therapeutic applications. Traditional as well as novel approaches to therapeutics will be discussed, as well as the role of drug resistance and strategies for its management.

GBS 776. Cancer Biology Journal Club. 1 Hour.

This journal club will discuss peer-reviewed scientific articles of interest to structural biology community. In general, the majority of the aricles will contain macromolecular structural data determined by one or more of the following methods: X-ray cyrstallography, cryo-EM, NMR and Mass Spectroscopy. It will help student become more familiar with our present understand of the structure/function for different classes of macromolecules and gain an appreciation of state of the art biophysical techniques available to determine macromolecular structures.

GBS 777. Cancer Biology Seminar. 1 Hour.

Required of Cancer Biology Theme students. Seminars on various topics in cancer biology or other biomedical science topics. Students will attend a seminar offered by a Joint Health Sciences department/theme, keeping a journal that includes each seminar date, title and a brief synopsis of the seminar. Journals are to be kept electronically and emailed in on time. Anyone turning in a journal after deadline will receive NP for the course.

GBS 778. Cancer Metastasis. 3 Hours.

The majority of cancer associated deaths are due to complications arising from metastatic disease. The process of metastasis is highly selective and is the result of a tumor cell completing a series of complex interrelated steps. Despite our improved knowledge of this disease, we still do not fully understand the molecular mechanisms regulating tumor progression and metastasis. This advanced course will cover basic mechanisms of how a tumor cell progresses from growth at the primary site to forming an overt lesion in a secondary organ and techniques used to study this disease.

GBS 779. Translational Research in Cancer. 3 Hours.

This course covers topics from setting a team, animals, to clinical models.

GBS 780. BSB Lab Methods. 2-3 Hours.

Course is required for first-year BSB themed students. This is a laboratory course in which students will gain hands-on experience in: cloning and expression of recombinant proteins, protein purification, mass spectrometry, NMR spectroscopy, crystallography, recombineering to produce knockout and knockin vectors, gene targeting in murine ES cells, microinjection of ES cells into blastocysts, genotyping of knockin/knockout mice, reprogramming of skin fibroblasts into induced Pluripotent Stem Cells (iPS).

GBS 781. Molecular Enzymology. 2 Hours.

Course intends to touch on the various mechanisms of enzymes in biological systems.

GBS 782. Molecular Genetics. 2 Hours.

Course studying the structure and function of genes at a molecular level.

GBS 783. RNA Biology. 2 Hours.

Course exploring the biology, biochemistry, structure and function of RNA at a research level. Course required for first year BSB theme students.

GBS 784. Stem Cell Biology. 2 Hours.

This course will explore the derivation, manipulation, and differentiation of embryonic, fetal, and adult stem cells in both mice and humans. Topics to be discussed include stem cell self-renewal, teratoma formation, hematopoietic stem cells, neural stem cells, trans-differentiation, nuclear transfer, and reproductive and therapeutic cloning. The course will be a mixture of instructor lectures and interactive journal club style presentations from the current stem cell literature by the students. Students will be evaluated based upon their journal article presentations, participation in class discussions, quizzes, and attendance.

GBS 786J. Journal Club in Structural Biology. 1 Hour.

The journal club will discuss peer-reviewed scientific articles of interest to the structural biology community. In general, the majority of articles will contain macromolecular structural data determined by one or more of the following methods: X-ray crystallography, cryo-EM, NMR and Mass Spectroscopy. It will help students become familiar with our present understanding of the structure/function for different classes of macromolecules and gain an appreciation of state-of-the-art biophysical techniques available to determine macromolecular structures.

GBS 787. Special Topics in Advanced Immunology. 1-4 Hour.

Varying topics offered to advanced graduate students.

GBS 788. Special Topics in Advanced Neuroscience. 1-4 Hour.

Varying topics offered to advanced graduate students.

GBS 789. Evolutionary Developmental Biology. 2 Hours.

The class is aimed at introducing the concepts of evolution and describing how changes in gene expression and function during embryonic development represent the central molecular mechanism underlying evolution.

GBS 790. Clinical Evaluation of Cognitive Disorders. 2 Hours.

This course will provide clinical exposure to the evaluation and care of patients with cognitive disorders through a combination of didactic sessions and practicum visits, including observation of visits for patients with developmental and age-related cognitive impairment, neuropsychological testing, and functional MRI.

GBS 791. Graduate Neuroscience Discussion. 1 Hour.

This course is a companion to the GBS Neuroscience Theme core curriculum modules for first year students in the Neuroscience Theme only. Students will participate in journal club style discussion on current topics in neuroscience research and develope presentation skills. If you are not in the Neuroscience Theme but would like to take this course, contact the course master for permission.

GBS 792. CMDB Seminar. 1 Hour.

Seminars on various topics in cellular and molecular biology or other biomedical science topics. Students will attend a seminar offered by a Joint Health Sciences department/theme, keeping a journal that includes each seminar date, title and a brief synopsis of the seminar. The journal will be turned in to the theme program office at the end of the semester.

GBS 793. Alzheimer's and Frontotemporal Dementia Journal Club. 1 Hour.

Journal Club. Discussion of important current research on Alzheimers disease and frontotemporal dementia, with a focus on basic and translational science.

GBS 794. Lab Rotation 4. 1-9 Hour.

Rotation for students needing a fourth rotation.

GBS 795. Lab Rotation I. 1-6 Hour.

First rotation for first year GBS Theme students.

GBS 796. Lab Rotation 2. 1-5 Hour.

Second rotation for first year GBS Theme students.

GBS 797. Lab Rotation 3. 1-9 Hour.

Third lab rotation for first year GBS theme students.

GBS 798. Non-Dissertation Research. 1-12 Hour.

Lab hours for students in the GBS Theme who have not entered candidacy.

GBS 799. Dissertation Research. 1-12 Hour.

Lab hours for students in the GBS Theme who have entered candidacy.
Prerequisites: GAC D

GBSC-Grad Biomedical Sciences Courses

GBSC 700. Journal Clubs. 1 Hour.

Journal Clubs.

GBSC 701. Seminars. 1 Hour.

Seminars.

GBSC 703. Bioinformatics Courses. 1-6 Hour.

Various Bioinformatics courses.

GBSC 704. Practical Course in Cryo-Electron Microscopy. 2 Hours.

This is a two-week practical course in high resolution electron microscopy (EM) with emphasis on cryo-EM and the preparation and observation of frozen-hydrated particulate samples such as protein complexes, viruses and whole bacterial cells. The first week will cover some theoretical aspects and general EM theory in morning lectures, followed by practicals and demos in the afternoon. The second week will consist of independent, hands-on practical work on the Tecnai F20 cryo-electron microscope. Students have the opportunity to work on their own samples. Open to all grad students but especially to those needing cryo-EM for research. Faculty, postdocs, and technicians may also attend, if space allows; class size is usually limited to 8.

GBSC 705. Protein Mass Spectrometry. 3 Hours.

Students participating in this course become familiar with standard analysis of proteins and protein mixtures by analytical mass spectrometry. This includes the analysis of recombinant and native isolations of proteins including the analysis of post translational modifications. The first month of the course will focus on the fundamentals of mass spectrometry and protein analysis and will be open to first year students. The second and third months of the course is followed by an applications section for students who have completed their first year course requirements. Included topics throughout the course include, sample preparation, mass spectrometry instrumentation, mass spectral interpretation, proteomic experimentation, database searching, analysis of protein modifications, targeted analysis of proteins in complex mixtures, and structural techniques in mass spectrometry.

GBSC 706. NMR Spectroscopy. 3 Hours.

The main purpose of this course is to provide fundamental understanding (physics) to graduate students who want to utilize NMR spectroscopy as a major tool in their structural biology research. Students with elementary Quantum Mechanics background will gain the optimum benefit from this course. The course is offered every two years. This course covers basic NMR Theory and Concepts (Nuclear Spin-1/2, Bloch Equations, FT-NMR, Rotating Frame, Various Relaxation Mechanisms, Chemical shits, J couplings, etc.), Density Matrix Theory, Product Operator Description of 2D- and 3D-NMR, Nuclear Overhauser Effect, Conformational Exchange, Solomon-McConnel equations, Residual Dipolar Couplings, NMR spectra of Amino acids, Peptides and Proteins, Solvent Suppression Methods, Random Coil Chemical shifts, 2D-NMR methods for assignments and structure calculations of peptides and small proteins, 3D/4D-NMR methods for assignment and structure studies of large proteins, CYANA Structure-Refinement calculations, NMR of nucleic acids, Protein Dynamics, and study of Protein-Ligand complexes including applications in drug design (STD-NMR, trNOESY, SAR-by-NMR and ILOE).

GBSC 707. Metabolic Regulation of Gene Expression. 3 Hours.

This course will focus on the impact of various metabolites on gene expression, cell growth, and differentiation in health and disease. The key topics for discussion will include the types of biologically active molecules in mammalian tissues, the mechanisms that regulate their concentrations at different stages of life, and the mechanisms by which these bioactive molecules regulate gene transcription through binding to nuclear receptors/transcription factors. Primary literature applicable to these topics will be the basis for discussion. Each section on a specific type of signaling molecule will start with an introductory lecture, followed by student presentations focusing on various aspects of the topic. The goal of this course is to familiarize students with the mechanisms of action and diversity of bioactive metabolic compounds that directly affect the expression of proteins at the level of gene transcription as well as mRNA translation during development and in adulthood.

GBSC 708. Protein Purification & Characterization. 3 Hours.

Protein purification is the process of isolating a single type of protein or protein complex from mixture. It is critical for further characterization of protein function and structure. This course covers currently used approaches for protein purification and characterization. The format will integrate classroom lecture with demonstration. The goal of this course is to equip students with the fundamental knowledge needed to work with proteins.

GBSC 709. Advanced Stem Cell Biology & Regenerative Medicine. 4 Hours.

Patient-specific cell therapies promise to transform medicine in the next two decades. In order for these regenerative therapies to be safe and effective, basic mechanisms of stem cell biology must be better understood. The goal of this course is to provide students with the basic science foundation to contribute to this field and to provide examples of translating this information to next generation medical therapies.

GBSC 710. Advanced Chromatin Biology. 3 Hours.

Chromatin biology may hold the keys for discovery of novel cures for cancer and other chronic genetic diseases. Chromatin state directly influences the development of regenerative medicine. Over the last few years, there has been an explosion of new insights into chromatin biology. This course will focus on four key topics: chromatin structure and gene regulation, chromatin in cancer biology, chromatin in developmental biology, and practical approaches in chromatin research. The format will be 1/3 lecture and 2/3 student presentations. Primary literature related to these topics will be assigned for discussion. The goal of this course is to help students to understand the cutting edge knowledge in chromatin biology and to be able to address questions on chromatin in their own research.

GBSC 711. Advanced Genetics Study. 1-9 Hour.

Independent Study in Advanced Genetics.

GBSC 712. Evolution of Immunity. 3 Hours.

Every form of multicellular life on earth has the capacity to carry out host defense. In higher order vertebrates the necessity for immunity against pathogens has given rise to an elaborate and complex system that involves a variety of specialized cell types and effector molecules. How did this complex system evolve? This course will explore immunity across the animal kingdom with a special emphasis on points of convergent and divergent evolution of immune mechanisms and strategies.

GBSC 713. Epigenetics Discussion. 1 Hour.

This course provides the student with an exposure to a wide range of basic epigenetics research topics and will promote scientific literacy, discussion skills, and critical thinking skills. In addition, students will gain experience developing lectures and providing constructive criticisms to their peers.

GBSC 714. Applications of Microscopy. 3 Hours.

This course will provide GBS students and postdoctoral fellows with an in-depth background in the theory of modern microscopy analyses for researchers in the biomedical sciences complemented with hands-on practical exercises. The course will cover a wide range of fundamental and cutting-edge approaches with training in experimental design and technical limitations, specimen preparation, diverse uses of bright-field, simple epifluorescence, single and multiphoton confocal, high resolution, live-cell, and intravital microscopy. The course will also provide training in specialized applications such as particle tracking and co-localization, photo-activation, Ca2+ imaging, FRET, FRAP, FLIM, and TIRF, and methods for quantitative data analyses. The course will also cover image preparation for publication and ethical issues related to image manipulation. Mentor & Course Master Permission is required to take this course.

GBSC 715. Molecular Basis of Disease. 3 Hours.

This is an advanced, graduate course that explores the molecular and cellular mechanisms that underlie the causes, symptoms, and complications of various diseases, including diabetes, autoimmune diseases, atherosclerosis, and cancer. An integrative approach to the clinical, pathologic, biochemical, and molecular perspectives of diseases is introduced. This will help the students to understand how metabolic pathways, cell cycle regulation, signal transduction, transcription factors, and protein glycosylation impacts on our ability to understand and treat human disease. Requirement: This course is designed for graduate students admitted to campus-wide PhD programs in the biomedical and basic sciences, post-doctoral fellows, medical students, residents, staff, and members of the faculty interested in the latest advances and approaches in understanding and treating human disease. Student must have successfully completed a doctoral level biochemistry/molecular biology course. If interested in this course, contact the course master before enrolling.

GBSC 716. Special Topics in Microbiology. 1-9 Hour.

Various topics in Microbiology.

GBSC 717. Protein/DNA Xray Crystallography. 3 Hours.

Xray crystallography is an important technique to resolve protein/DNA structures and it requires specialized training. Covered in this will not only be the theoretical aspects, but there will also be hands-on training sessions on each topic. Some topics covered: protein crystallization, data collection and reduction, structure solution, refinement and how to report structures.

GBSC 718. Epigenetics. 3 Hours.

Students will learn of changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence.

GBSC 719. Pattern Recognition Receptors. 2-3 Hours.

In recent years the study of innate immunity has made a resurgence and its critical role, not only in host defense against invading pathogens but in the development of adaptive immune responses, is now appreciated. This course will provide an in-depth look at selected aspects of the innate immune response including the cellular and molecular components critical to its development. A particular focus will be innate immune mechanisms driven by pattern recognition receptors and their ligands. The course will involve invited lecturers and student presentations on selected topics.

GBSC 720. Journal Club 2. 1 Hour.

This will house various journal clubs, differentiated by Section numbers. To be considered like a Special Topics course.

GBSC 721. Brain Tumor Biology. 3 Hours.

Brain Tumor Signaling, Biology & Therapeutics Course. This course will review the types of adult and pediatric brain tumors with a focus on 3 major components: 1-cellular genetics and signaling, 2-pro-tumorigenic cellular biology, and 3-preclinical models and clinical treatments. At the end of the course, the student should have a thorough understanding of the changes in tumor vs. normal tissue that promote cancer initiation and growth. The student should understand how these changes provide the foundation for current and cutting edge treatment strategies. The focus will be on gliomas, but other tumors will be discussed.

GBSC 722. Special Topics. 1-9 Hour.

Courses offered for only 1 semester.

GBSC 723. Career Dev Courses. 1-9 Hour.

Various courses relating to Career Development.

GBSC 724. Metabolomics. 3 Hours.

The goal of the course is to provide training on (1) the new vision of the chemical composition of the metabolome, (2) its impact on phenotypes in normal health and disease, (3) how to design experiments that (a)reduce systematic variation and (b) deal with the effects of the microbiome, (4) recovery of the metabolome from body fluids/excreta, cells and tissues, (5) analytical methods used in metabolomics, (6) post-acquisition data processing and univariate and multivariate statistical analysis, (7) metabolite confirmation, (8) unknown (new) metabolite identification, (9) pathway analysis, (10) targeted quantitative analysis of specific pathways, (11) use of stable-isotopically labeled precursors to measure pathway dynamics, (12) metabolomics in human and animal models of disease (atherosclerosis, cancer, diabetes, eye diseases, immune diseases and neurodegeneration), (13) metabolomics in situ (imaging mass spectrometry and direct analysis in the clinic and the operating room) and (14) integration of metabolomics with other 'Omics (genomics, transcriptomics and proteomics).

GBSC 725. Cancer & Micro Environment. 3 Hours.

The growth and progression of cancer is closely regulated by the tumor microenvironment. Through this course students will gain a comprehensive understanding of the tumor microenvironment by studying topics that include, for example, the cellular and a cellular composition of the microenvironment, mechanisms of communication between tumor and host cells and how the tumor microenvironment promotes tumor growth, metastasis and drug resistance. Students will also learn the in vitro and in vivo models utilized for studying the tumor microenvironment and current approaches for targeting the tumor microenvironment for cancer therapy.

GBSC 726. Science Communication & Review. 2 Hours.

This course will familiarize students on four major components of science communication and review: 1) how to read and review scientific manuscripts, 2) how to review scientific proposals, 3) how to give effective poster presentations and elevator summaries, and 4) how to give an oral research presentation. The course will offer the opportunity for students to be fluent and effective communicators and scientific reviewers.

GBSC 727. Neuro Systems. 2 Hours.

Systems neuroscience studies how neural circuits and systems work together to create behavior. This course is a short overview of systems neuroscience ideas and concepts, from alpha oscillations to zebra-finch song.

GBSC 728. Cancer Genomics, Epigenetics, & Therapeutics. 3 Hours.

Recent advances in high throughput technologies have enabled researchers to decipher the genomic and epigenetic alterations in cancer in great detail. In this course “Cancer Genomics and Epigenetics”, students will learn the technologies used for investigating the genomic and epigenetic alterations in cancer and effect of these changes on cancer progression and potential application of understanding these changes. The goal of this course is to provide the students with an exposure to a wide range of high throughput technologies used in cancer genomic research, basic and translational genomic and epigenetics research. In addition, the course will highlight the major discoveries in the area of gene mutations and gene fusions as well as therapeutic targeting some of the critical molecular alteration. This course will give exposures to students to state of the art cancer research topics, promotes scientific literacy, discussion skills, and critical research integration skills. In addition, students will also gain experience in presentation and ideas to develop new projects in cancer genomics and epigenetics research areas.

GBSC 729. Cell Neurophysiology. 2 Hours.

This course is required for first year Neuroscience theme students. Course presents the fundamental principles of how nerve cells work. Starting with ion channels themselves, it integrates them into the functioning of individual neurons. The way in which voltage-dependent ion channels act in concert to generate action potentials and synaptic potentials is discussed in the framework of basic physical laws. The mechanisms of transmitter release and the postsynaptic actions of transmitter are studied. The overall aim is to provide students with a quantitative understanding of how individual nerve cells communicate with each other.

HMG-Hughes Med Grad Fellowship Courses

HMG 701. Hughes Med Grad Journal Club. 1 Hour.

Weekly journal club seminar for faculty and students in the Hughes Med-Grad Fellowship Program. Students will present updates on thesis research and/or recent papers from peer reviewed journals. Faculty are encouraged to attend.

HMG 702. Phenotyping Human Disease. 2 Hours.

Introduction to the study of human disease and translational research. The course will consist of several 2-week modules, each covering a different disease. Each module will consist of two types of lectures. During the first week of each module, a physician scientist will discuss human patients and case studies of the disease. In the second week of each module, a basic science researcher will discuss the animal models used to study the same disease.

HMG 703. Quantitative Methods. 2 Hours.

The primary goal of this course is to teach statistical methods by describing clinical data that led to specific hypotheses and then discuss the different statistical tools needed to test these hypotheses. Each lecture will focus on how a particular statistical method was applied to the analysis of a particular disease. In addition, important historical manuscripts related to medical statistics will be used as examples of this integrated approach.

HMG 704. Modeling Human Disease. 2 Hours.

Introduction to the study of disease-based research. Format will consist of clinical-pathobiological conference-style experience where students will present patient cases and researchers will discuss molecular basis of each disease.

HMG 705. Vocabulary in Drug Discovery. 2 Hours.

This course will enable the student to follow the pipeline of drug discovery from target selection to FDA approval. Additional lectures will cover cancer drugs and targets, mechanisms of drug action, chemical synthesis, drug screening, lead development, metabolism, bioavailability, preclinical efficacy and toxicity assessment, and will emphasize issues of clinical trial design.

HMG 706. Hughes Med-Grad Journal Club. 1 Hour.

Journal Club for students in the Hughes Med-Grad Fellowship Program. Students will present updates on their thesis research and/or a recent paper from a journal. Faculty are encouraged to attend.

HMG 707. Vocabulary in Clinical Research. 1 Hour.

Students will be exposed to basic topics in clinical research and learn the details involved in designing cliniclal trials. Students will also sit in as ad-hoc members of the Scientific Advisory Committee of the UAB General Clinical Research Center and learn about the review process for human/clinical research trials.

HMG 714. Modeling Human Disease II. 2 Hours.

Introduction to the study of disease-based research. The format will consist of clinical-pathobiological conference-style experience where students will present patient cases and researchers will discuss molecular basis of each disease. This course is designed for 2nd year students that are expected to provide more of a leadership role (coordinate faculty/patient presentations).

HMG 724. Modeling Human Disease III. 2 Hours.

Introduction to the study of disease-based research. The format will consist of clinical-pathobiological conference-style experience where students will present patient cases and researchers will discuss molecular basis of each disease. This course is designed for 3rd year students that are expected to serve as group leaders and facilitate discussion.

IBS-Integrative Biomedical Sci Courses

IBS 700. Biological Chemistry and Cellular Physiology. 10 Hours.

The purpose of this course is to provide students a rigorous background in the translational principles of biological chemistry and cellular physiology. The principles taught here are those that all students in the biomedical sciences should master. The students will then apply the knowledge acquired in IBS-I to organ-system physiology, pathophysiology, and pharmacology.

IBS 701. Pathophysiology and Pharmacology of Disease. 8 Hours.

The purpose of this course is to integrate physiological, pathophysiological and pharmacological principles of tissue and whole organbiology. Students will use an organ-system based approach to understand physiological processes in normal and diseased settings and the rational pharmacological approach in treating these disorders. The material masteredin IBS-II will facilitate understanding in genetic-based disorders and genetically-generated animal models of disease provided in IBS-III.

IBS 702. Genetics and Genetic Disease. 3 Hours.

The purpose of this course is to provide a molecular understanding of genetically-based human diseases and the role that animal models play in studying human disease. Students will be provided a basic background in genetics and a thorough analysis of the importance of altered gene productsin diesases. Also covered is an analysis of the role of infectious agents in diesase, emerging diseases, and new technologies in understandingthe role of gene products in physiology, pathophysiology and therapy.

IBS 703. Biology of Neoplasia. 3 Hours.

Advanced graduate elective surveying cancer from molecular mechanisms to whole animals. Clinical Correlates also included. Coreq: IBS or CMB first-year courses or related courses.

IBS 706. Mitochondrial basis of Human Disease. 2 Hours.

Provides an interactive forum for faculty and students to discuss recent advancements in the field of mitochondrial biology with particular emphasis on the important role of mitochondrial dysfunction in human disease.

IBS 707. Cancer Biology. 2 Hours.

Provides a comprehensive coverage of molecular and cellular aspects of carcrmogenesis as well as clinical issues related to human cancer.

IBS 708. Modern Drug Design and Development. 2 Hours.

This course takes a translational look at drug discovery from the fundamentals to detect the potential of anticancer compounds to the implementation of clinical studies.

IBS 709. New Perspective in Cardio Bio. 2 Hours.

Course will consist of didaetic lectures given by faculty members from UAB and guest lectures from other institutions on a specific topic in the filed of cardiovascular biology.

IBS 711. Principles of Toxicology. 2 Hours.

Introduces the interdisciplinary filed to toxicology by laying the foundation for understanding how chemicals can have an adverse effect on living organisms and the mechanisms by which chemicals exert their topic effects.

IBS 798. Non-Dissertation research. 1-4 Hour.

Non-dissertation research. Only open to first-year IBS students.

JHS-Joint Health Sciences Courses

JHS 500. BioTeach. 6 Hours.

For teachers of science courses. Hands on exrepience. McWane Center.

Faculty